教授:陈铭
Email :chenming0228@cczu.edu.cn
个人主页:https://www.x-mol.com/groups/chenming
2006/09-2010/06,苏州大学 材料与化学化工学部,学士学位.
2010/09-2015/06,中国科学院上海有机化学研究所,博士学位. 导师:刘元红 研究员
工作经历:
2015/07-2016/06,中国科学院上海有机化学研究所, 刘元红研究员课题组 研究助理.
2016/08-2020/11, 美国芝加哥大学,博士后,导师: Prof. Guangbin Dong.
2021/03-至今,新浦京8883平台,教授
个人荣誉:
2021年,入选江苏省特聘教授
2015 年,刘铸晋优秀博士生奖学金;
2015 年,中国科学院大学优秀毕业生;
2015 年,北京市普通高等学校优秀毕业生;
研究方向:
围绕有机化学为中心,旨在解决有机合成化学中长期存在的挑战性课题。
主要以过渡金属催化为手段,通过设计合成新型的催化剂、配体,发展高活性、
实用的有机合成方法学,实现一些重要的(手性)合成砌块的高效合成。
教学科研项目:
教学:基础化学实验,研究生波谱分析(理)
科研项目:国自然青年科学基金项目,领军型创新人才引进培育项目C类
发表论文:
Publications in CCZU:
11. Tang, Lu-ning.; Liu, Guo-ying.; Li, Jun-hua and Chen, Ming.*Palladium-Catalyzed Diversified Synthesis of mono-Fluorinated Alkenes from Allylic gem-Difluorides through Pd-OH intermediate. Org. Lett.2023, 25, 9064-9069. DOI:10.1021/acs.orglett.3c03917.
10. Yang, Sen.; Hu, Hao.; Li, Jun-hua and Chen, Ming.* Direct Alkylation of Glycine Derivatives via Photoinduced Palladi-um Catalysis, Utilizing Intermolecular Hydrogen Atom Transfer Mediated by Alkyl Radicals.
ACS Catalysis. 2023, 13, 24, 15652−15662. DOI:10.1021/acscatal.3c04075.
9. Kong, Xian-qiang.; Chen, Yi-yi.; Chen, Xiao-hui.; Ma, Cheng.; Chen, Ming.; Wang, Wei.; Xu, Yuan-Qing.; Ni, Shao-Fei.; Cao, Zhong-Yan.* Organomediated electrochemical fluorosulfonylation of aryl triflates via selective C–O bond cleavage.
Nat. Commun. 2023, 14, 6933.
DOI: 10.1038/s41467-023-42699-0.
8. Yang, Sen.; Hu, Hao.; and Chen, Ming.* Photoinduced Palladium-Catalyzed Regio- and Chemoselective Elimination of Primary Alkyl Bromides: A Mild Route to Synthesize Unactivated Terminal Olefins.
Org. Lett. 2023, 25, 7968-7973. DOI: 10.1021/acs.orglett.3c02980.
7. Chen, Jia-ming.; Li, Jun-hua.; Xie, Li-cheng.; Fan, Hui-ke.; Sheng, Xia-xin.; Du, Yu-jia.; Liu, Guo-ying.; Hu, Hao.; Jiang, Yan*.; and Chen, Ming.* Iron-Catalyzed Divergent Approach to Naphthyridinones and Quinolinones: Leveraging Povarov and Carbonyl-Alkyne Metathesis Reactions of Electron Deficient Alkynes.
Org. Chem. Front. 2023, 10, 5505-5511. DOI:10.1039/D3QO01302B.
6. Li, Pei-shang.; Teng, Qiaoqiao*.; and Chen, Ming.* Photoinduced Radical Cascade Domino Heck Coupling of N-Aryl Acrylamide with Vinyl Arenes Enabled by Palladium Catalysis. Chem. Commun. 2023, 59, 10620-10623. DOI: 10.1039/D3CC03506A.
5. Yang, Sen.; Guo-ying, Liu.; Fan, Huike.; Jun-hua, Li.; Teng, Qiaoqiao*.; and Chen, Ming.* Sodium Hydroxide (NaOH)-Mediated Oxidative Hydroxylation of Arylboronic Acids and Its Applications in C-O Bond Formation.
Eur. J. Org. Chem. 2023, e202300517. DOI: 10.1002/ejoc.202300517.
(Dedicated to celebrate the 45th anniversary of Changzhou University)
4. Sheng, Xiaxin†.; Du, Yujia†.; Li, Junhua.; Teng, Qiaoqiao.*; and Chen, Ming.* Photo-induced Nitrogen-to-Alkyl Radical Relay Heck Reaction of o-Alkylbenzamide with Vinyl Arenes by Palladium Catalysis. Org. Lett. 2023, 25, 3664-3669. DOI : 10.1021/acs.orglett.3c01030.
3. Du, Yujia†.; Sheng, Xiaxin†.; Li, Junhua.; Chen, Jiaming.; Yang, Sen. *; and Chen, Ming.* Aryl-to-Alkyl Radical Relay Heck Reaction of Amides with Vinyl Arenes. Chem.Sci. 2023, 14, 3580-3586. DOI: 10.1039/D2SC06852D.
2. Fan, Huike, Yang, Sen.; Li, Junhua.; Teng, Qiaoqiao*.; and Chen, Ming.* BaO-Catalyzed α-Deuteration of Ketones, Sulfones, Sulfoxides, and Nitriles. Eur. J. Org. Chem. 2022, e202201218. DOI: 10.1002/ejoc.202201218.
1. Yang, Sen.; Fan, Huike.; Xie, Licheng.; Dong, Guangbin*.; and Chen, Ming.* Photoinduced Desaturation of Amides by Palladium Catalysis. Org. Lett. 2022, 24, 6460-6465.
Publications prior to CCZU:
1. Chen, M.; Chen, Y.; Sun, N.; Zhao, J.; Liu, Y.* Gold-Catalyzed Oxidative Ring Expansion of 2-Alkynyl-1,2-Dihydropyridines or -quinolines: Highly Efficient Synthesis of Functionalized Azepine or Benzazepine Scaffolds. Angew. Chem. Int. Ed.2015,54, 1200.
2. Chen, M.; Dong, G.* Direct Catalytic Desaturation of Lactams Enabled by Soft Enolization.J. Am. Chem. Soc.2017, 139, 7757. (Highlighted by Org. Process Res. Dev. 2017, 21, 1873.)
3. Chen, M.; Liu, F.; Dong, G.* Direct Palladium-Catalyzed β-Arylation of Lactams. Angew. Chem. Int. Ed. 2018,57, 3815.
4. Chen, M; Rago, A; Dong, G* Platinum-Catalyzed Desaturation of Lactams, Ketones and Lactones. Angew. Chem. Int. Ed. 2018, 57, 16205. (Highlighted by Synfacts, 2019, 173)
5. Chen, M.; Dong, G.* Copper-Catalyzed Desaturation of Lactones, Lactams and Ketones under pH-Neutral Conditions.J. Am. Chem. Soc.2019, 141, 14889.
6. Chen, M.; Dong, G.* Platinum-catalyzed α,β-Desaturation of Cyclic Ketones through Direct Metal-enolate Formation. Angew. Chem. Int. Ed. 2021, 60, 7956.
7. Chen, M.; Chen, Y.; Liu, Y.* Palladium-catalyzed highly efficient synthesis of tetracenes and Pentacenes.Chem. Commun.2012, 48, 12189.
8. Chen, M.; Liu, J.; Wang, L.; Zhou, X.; Liu, Y.* Gold-catalyzed cascade cycloisomerization of 1,7-diyn-3,6-bis(propargyl carbonate)s: stereoselective synthesis of naphtho[b]cyclobutenes. Chem. Commun.2013, 49, 8650.(Highlighted by Synfacts, 2014, 144)
9. Chen, M.; Sun, N.; Liu, Y.*Environmentally Benign Synthesis of Indeno[1,2-b]quinolines via an Intramolecular Povarov Reaction.Org.Lett.2013, 15, 5574.
10. Chen, M.; Sun, N.; Xu, W.; Zhao, J.; Wang, G.; Liu, Y.* Gold-Catalyzed Ring Expansion of alkynyl heterocycle via 1,2-Migration of an Endocyclic C-Heteroatom Bond. Chem. Eur. J,2015, 21, 18571.
11. Chen, M†.; Sun, N†.; Chen, H.; Liu, Y.* Dioxazoles, a new mild nitrene transfer reagent in gold catalysis: highly efficient synthesis of functionalized oxazoles. Chem. Commun.2016, 52, 6324.
12. Chen, Y.; Chen, M.; Liu, Y.* Gold-Catalyzed Cyclization of 1,6-Diyne-4-en-3-ols: Stannyl Transfer from 2-Tributylstannylfuran Through Au/Sn Transmetalation.Angew. Chem. Int. Ed.2012, 51, 6181.
13. Chen, Y.; Chen, M.; Liu, Y.* Gold-Catalyzed Cascade Cyclizations of 1,6-Diynyl Carbonates to Benzo[b]fluorenes Involving Arylation of Oxocarbenium Ion Intermediates and Decarboxylative Etherification.Angew. Chem. Int. Ed.2012, 51, 6493. (Highlighted by Synfacts2012, 969).
14. Sun, N.; Chen, M.; Liu, Y.* Gold-Catalyzed Oxidative Reactions of Propargylic Carbonates Involving 1,2-Carbonate Migration: Stereoselective Synthesis of Functionalized Alkenes. J. Org. Chem,2014, 79, 4055.
15. Liu, J.; Chen, M.; Zhang, L.; Liu, Y.* Gold(I)-Catalyzed 1,2-Acyloxy Migration/[3+2] Cycloaddition of 1,6-Diynes with an Ynamide Propargyl Ester Moiety: Highly Efficient Synthesis of Functionalized Cyclopenta[b]indoles. Chem. Eur. J.2015, 21, 1009.
16. Li, X.; Chen, M.; Xie, X.; Sun, N.; Li, S*.; Liu, Y*. Synthesis of Multiple-Substituted Pyrroles via Gold(I)-Catalyzed Hydroamination/Cyclization Cascade. Org. Lett.2015, 17, 2984.
17. Sun, R.; Liu, J.; Yang, S.; Chen, M.; Sun, N.; Chen, H.; Xie, X.; You, X.; Li, S.; Liu, Y.* Cp2TiCl2-Catalyzed cis-Hydroalumination of Propargylic Amines with Red-Al: Stereoselective Synthesis of Z-Configured Allylic Amines. Chem. Commun.2015, 51, 6426.
18. Xu, W.; Chen, M.; Sun, N.; Liu, Y.* Gold-catalyzed cyclization of 1,6-diynyl dithioacetals via 1,7-carbene transfer and aromatic C–H functionalization.Chem. Commun.2016, 52, 11000.
19. Hu, H†.; Hu, X†.; Chen, M.; Sun, N.;* Liu, Y.* Gold-Catalyzed Ring Expansion Reaction: Highly Efficient Synthesis of Functionalized 2,3-Benzodiazepine Scaffolds.Chin. J. Org. Chem.2018, 38, 190.
授权专利:
专利:一种α-氘代酮、腈、亚砜类化合物的的制备方法. 陈铭,樊慧柯. 申请号:202210465715.9
专利:一种烯丙基单氟化合物的合成方法.陈铭,刘国营,唐路宁. 申请号:202310058291.9
专利:可见光驱动非天然氨基酸及其衍生物的合成方法. 杨森; 陈铭;胡浩. 申请号:202310791881.2
专利:抗肿瘤活性分子苯并[b]氮杂卓衍生物及其合成方法和应用. 陈铭;杜俞佳; 盛夏鑫. 申请号:202311141245.1.
5. 专利:单氟1,4-烯炔类化合物的合成方法.陈铭,刘国营,申请号:202311476602.X
6. 刘元红,陈铭,陈宜峰, 并四苯及并五苯类化合物的合成方法, 中国发明专利,申请号: 201210359027. 申请日期:2012-9-24. 专利号:CN103664499A. (导师为第一作者)